Maternal microchimerism
نویسندگان
چکیده
منابع مشابه
Pregnancy, Microchimerism, and the Maternal Grandmother
BACKGROUND A WOMAN OF REPRODUCTIVE AGE OFTEN HARBORS A SMALL NUMBER OF FOREIGN CELLS, REFERRED TO AS MICROCHIMERISM: a preexisting population of cells acquired during fetal life from her own mother, and newly acquired populations from her pregnancies. An intriguing question is whether the population of cells from her own mother can influence either maternal health during pregnancy and/or the ne...
متن کاملFetal cell microchimerism in the maternal heart: baby gives back.
In this issue of Circulation Research, Kara et al1 present an elegant series of experiments demonstrating that after murine maternal myocardial infarction, fetal cells engraft and differentiate into endothelial cells, smooth muscle cells, and cardiomyocytes at the site of injury. These cells, when isolated and cocultured with neonatal cells, appear to be capable of differentiating into beating ...
متن کاملMicrochimerism of maternal origin persists into adult life.
Recent studies indicate that fetal cells persist in maternal blood for decades after pregnancy. Maternal cells are known to engraft and persist in infants with immunodeficiency, but whether maternal cells persist long-term in immunocompetent offspring has not specifically been investigated. We developed sensitive human leukocyte antigen-specific (HLA-specific) PCR assays and targeted nonshared ...
متن کاملMaternal microchimerism in muscle biopsies from children with juvenile dermatomyositis
OBJECTIVE Recent advances in molecular techniques have revealed that there is bi-directional transfer of cells between mother and child during pregnancy, and the presence of a mother's cells in her child has been termed maternal microchimerism (MMc). There is the potential for maternal cells to provoke inappropriate immune responses in the child, which could be a factor in autoimmunity includin...
متن کاملPretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother
AIM To investigate the rates of pretransplantation fetal-maternal microchimerism (MC) and its effect on rejection in children receiving maternal liver grafts. METHODS DNA or blood samples before liver transplantation (LT) were available in 45 pediatric patients and their mothers. The presence of pretransplantation MC to non-inherited maternal antigens (NIMAs) (NIMA-MC) in the peripheral blood...
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ژورنال
عنوان ژورنال: Chimerism
سال: 2014
ISSN: 1938-1956,1938-1964
DOI: 10.4161/chim.29870